The Estevan Police Service received a report late Thursday night about a collision on Highway 47.
The head-on collision had injuries when the police arrived on the scene.
Both vehicles were damaged beyond repair. Their drivers were the sole occupants.
Two people were transported to a hospital by EMS.
STARS Air Ambulance reported on Twitter that they were dispatched to Estevan for a scene-call emergency.
STAR-9 (Regina) has been dispatched for a scene call emergency in the Estevan, SK area.— STARS air ambulance (@STARSambulance) August 5, 2022
STARS also posted a Tweet saying they were dispatched to Estevan for an inter-facility transfer on Thursday night.
There's no word on whether one or both of the missions were related to the collision.
The matter is still under investigation.